| Yakima Valley | Columbia Valley | Walla Walla Valley | Puget Sound | Red Mountain | Columbia Gorge | Horse Heaven Hills | Wahluke Slope | Rattlesnake Hills | Snipes Mountain | Lake Chelan |

• Lies in the Columbia River Plateau, through much of central and southern Washington state, with a small section crossing into the neighboring state of Oregon
• Largest wine region in the state of Washington, including over 11,000,000 acres (45,000 km2), of which 17,000 acres (69 km2) are planted in vineyards
• Included within its confines are six other American Viticultural Areas (AVA) including Yakima Valley, Red Mountain, Walla Walla Valley, Horse Heaven Hills, Rattlesnake Hills and Wahluke Slope
• Grapes grown here include Merlot, Riesling, Cabernet Sauvignon, Chenin Blanc, Sauvignon Blanc, and Sémillon
• The Cascade Range forms its western boundary with the Palouse regions bordering the area to the east
• To the north, the Okanogan National Forest forms a border with the AVA and Canada
• The Columbia valley stretches between the 46th parallel and 47th parallel which puts it in line with the well known French wine growing regions of Bordeaux and Burgundy
• The volcanic and sandy loam soil of the valley offers good drainage and is poor in nutrients, ideal in forcing the vine to concentrate its resources into the grape clusters
• Array of diverse microclimates among the various sub-appellations, but the whole region shares the common climate traits of cold winters and long dry growing seasons with low humidity (perfect for “balanced” wines)
• Deep winter freezes are the main climate threat to the grape growing industry of the Columbia Valley 
• Many vineyards incorporate wind turbines to keep air circulating around the grapes and stay warm enough to prevent frost
• Average rainfall is less than 6 inches in some areas
• Using water from the nearby Columbia, Snake, Yakima and Walla Walla rivers growers are able to precisely control the timing and amount of water that the vines receive